What are Cetrin tablets from: purpose, features of use and possible side effects. Tsetrin: indications for use, analogues of Tsetrin and pregnancy: concepts are incompatible

Cetrin has few side effects, however, it is contraindicated in pregnancy. It is especially undesirable to take this drug in the first 12 weeks of pregnancy, when the organs and tissues of the fetus are being laid. But even at a later date, the use of this drug is also contraindicated.

Allergies in pregnant women

If a woman suffers from an allergic disease, then it is sometimes impossible to predict in advance how the allergy will “behave” during pregnancy due to numerous, sometimes very individual changes in metabolism. that occur in her body during pregnancy.

During pregnancy, first of all, the hormonal background of a woman changes. , and under its influence - the speed of blood flow and metabolism . Due to the heavy load (two organisms - mother and child), the cleansing abilities of the liver and kidneys are reduced. As a result, all organs and tissues of a woman undergo significant and varied changes, which in turn can change the effect on the body of habitual and previously easily tolerated drugs beyond recognition.

All these changes can significantly increase the risk of drug allergy and exacerbate allergic diseases that began before pregnancy. In some women, during pregnancy, the allergic disease continues to proceed as usual, in others, all manifestations disappear or decrease. But worsening of the course of allergic diseases during pregnancy is especially dangerous - very rarely, but it happens.

Allergies in pregnant women most often manifest themselves in the form of an allergic rhinitis or conjunctivitis. Rarely, these are skin rashes and bronchial asthma. In all these cases, obstetrician-gynecologists recommend preparing for pregnancy, visiting an allergist in advance and, if necessary, conducting a course of specific treatment.

What to do if allergies increase during pregnancy

First of all, no initiative: all treatment should take place only under the supervision of a doctor. First, the doctor will try to cope with the allergy in non-drug ways: a hypoallergenic diet , excluding possible household allergens (including dust, particles of animal hair, fish scales, and so on).

If it is not possible to help a woman in this way, then medication is prescribed, including the safest antihistamines.

What are the dangers of antihistamines during pregnancy

Antihistamine drugs are used during pregnancy, but only under strict indications. The fact is that the drugs of this group block the action of histamine, a biologically active substance that is not completely superfluous in the body of a pregnant woman.

With the assistance of histamine, the fertilized egg is introduced into the wall of the uterus and the embryo develops in it. At later stages of pregnancy, histamine easily crosses the placenta and regulates the metabolism between the mother and fetus. The process of laying tissues and the development of fetal organs depends on its impact.

The use of antihistamine drugs can disrupt all these processes. And since there are practically no clinical trials on pregnant women, no one can say for sure how this or that antihistamine drug will affect the condition of the woman and the fetus.

In the first 12 weeks of pregnancy, these drugs can not be used categorically, but in the future they are used with caution, taking into account all indications and contraindications, the condition of the woman and the fetus is still sometimes used. But since there are no carefully tested and absolutely safe among antihistamines, their use should be under the constant supervision of a doctor.

The body of a pregnant woman reacts in a peculiar way to previously familiar products and phenomena. Therefore, it is not surprising that expectant mothers are prone to allergic reactions much more often than others: they have allergies in both mild and severe forms and depend on the use of certain drugs, the use of certain foods, or on a certain period of time when plants bloom or fruits ripen.

Pregnant women try to realize the natural desire to eliminate unpleasant symptoms and live a full life through anti-allergic drugs, but is it possible to use strong enough drugs, most of which have the ability to block histamine?

What is histamine and its role in the body of a pregnant woman

In addition to the fact that histamine is a well-known mediator of allergic reactions, it is also an equally well-known regulator of physiological processes. In a pregnant body, histamine becomes a very important hormone, in the earliest stages, thanks to this component, a fertilized egg attaches to the wall of the uterus, and in later periods, histamine contributes to the normal development of the fetus and becomes the main regulator of metabolism.

It depends on the amount of histamine in the mother's body in the future how adequately the tissues and organs of the baby will be formed.

Cetrin from a number of antihistamines

Which of the drugs to choose a pregnant woman with allergies? The first thing that comes to mind is Tsetrin. The medicine is effective, not very expensive, and advertising is placed in almost all mass media. But such an availability of the drug should, at a minimum, make the future mother think and consult a doctor.

Only a specialist can dissuade women who are too keen on self-medication of the need for therapy with conventional drugs. During pregnancy, you need to switch to less aggressive and more appropriate medicines for the current state of the woman.

Cetrin is excluded from their number, but if other anti-allergic drugs do not help, doctors make an exception by prescribing Cetrin to pregnant women, provided that they are taken with great care and constant monitoring on their part.

Cetrin represents the second generation of antihistamines and differs from first generation drugs in a milder effect on receptors and less side effects.

Composition, effects and pharmacokinetics of the drug

The active ingredient in Cetrin is cetirizine.

Excipients:

lactose;
magnesium stearate;
povidone;
corn starch.

The active substance at the cellular level binds to receptors and blocks the flow of histamine and prevents the manifestation of rash, itching, hyperemia.

Another feature of the effect of the drug is to effectively counteract the accumulation of eosinophils in the focus of inflammation and prevent the development of the inflammatory process.

Cetrizine is absorbed from the gastrointestinal tract, and food intake has little effect on absorption, so there is not much difference when taking the pill: before, after or during meals.

Metabolic processes are concentrated in the liver, the half-life is from 5 to 12 hours, depending on the age of the patient (the older he is, the longer the excretion).

The drug is excreted in the urine.

Indications for use

Allergic reactions that are seasonal or chronic in nature:

allergic rhinitis;
allergic conjunctivitis;
itching of various adventures;
hives;
angioedema.

Pregnancy as a contraindication

In the instructions for the drug, pregnancy and the lactation period are indicated by contraindications to the use of Cetrin. And any physician will confirm that taking drugs that suppress the effect of histamine in pregnant women can cause such negative consequences as a violation of the mental and physical development of the fetus.

As for the mother's well-being, pregnant women taking Cetrin often complain about the negative effect of the drug on the functioning of the kidneys and liver.

Therefore, even if the allergy is too painful, do not take the drug on your own - an easy solution can later be very expensive.

Tsetrin by trimesters

1 trimester

Up to and including the 12th week of pregnancy, Cetrine is strictly contraindicated. In the body of a pregnant woman during this period, such important processes as the fixation of the egg and the development of the embryo are carried out, so it is impossible to reduce the level of histamine.

2nd trimester

The development of the organs and systems of the fetus is very active, as are the metabolic processes that allow the baby to fully receive all the essentials from the mother's body. Histamine is involved in these processes, so blocking this component can lead to a lack of nutrients for the baby and slow development.

3rd trimester

The baby's body is almost formed, but this is not a reason to take a drug that is undesirable for pregnant women. Cetrin is prescribed only in exceptional cases and therapy is carried out under the strict supervision of a physician.

spuzom.com

Cetrin during pregnancy: instructions for use, contraindications

Against the background of increased production of histamine, nasal congestion, lacrimation are observed, natural breathing is disturbed, there is a sensation of itching and burning in the paranasal sinuses. The development of side effects is highly undesirable during the period of gestation.

The therapeutic regimen for pregnant women includes sparing antihistamines of the 3rd generation, among which Cetrin is widely used. The active ingredients are devoid of cardiotoxic sedative effect, have high selectivity, and are not addictive. Is it possible to drink "Cetrin" during pregnancy, and in what doses / course, so as not to harm the health of the baby and mother?

The feasibility of taking "Cetrin" at different gestation periods

The drug is presented on the pharmacological market as syrup and tablets coated with a multicomponent soluble coating. Regardless of the form of release, the main composition forms a competitive histamine antagonist - cetirizine.

Find out here which drops can be used during pregnancy to restore nasal breathing.

The H1 blocker of histamine receptors exhibits antipruritic, antiexudative and antiallergic activity. The therapeutic effect is enhanced by the presence of excipients in the composition: corn starch, lactose, povidone KZO.

"Cetrin" relieves the symptoms of an allergic reaction, prevents the development of pathological changes in the influence of antigens. The action of the drug is aimed at inhibiting the synthesis of stimuli, reducing the cells of the leukocyte germ, increasing the capacity of the capillaries.

The price range for tablets varies from 159 to 234 rubles

The components are rapidly absorbed in the gastrointestinal tract, the medical effect occurs within an hour after ingestion, lasts up to 24 hours.

The productivity and safety of "Cetrin" explains the fact that it does not affect serotonin and cholinergic nerve endings. Studies that would prove possible harm to the health of the mother and unborn child on patients have not been conducted.

For reference! The constituent components can be excreted with milk during breastfeeding, so antihistamines are prohibited during lactation.

According to the instructions for use of "Cetrin" during pregnancy, the drug is included in the therapeutic regimen at all stages of gestation, when the threat to the health of the mother and child outweighs the potential harm from taking the medication.

In order to prevent the risk of side effects, it is necessary to take an allergic agent according to the doctor's recommendations and under medical supervision.

The use of "Cetrin" in the 2nd trimester has a minimal toxic effect on the fetus. The laying of the internal organs is completed, the placenta is formed, the embryo is protected from the effects of the components of the drug.

Contraindications

Due to the fact that the drug is excreted from the body mainly by the kidneys, it is prescribed with caution to patients with a history of renal and hepatic insufficiency.

For reference! In the therapeutic scheme of the elderly, "Cetrin" is included in a reduced dosage.

In pediatrics, a pharmaceutical product is allowed from the age of six, mainly in the form of a syrup. With hypersensitivity of the body to individual components or overdose, the development of the following disorders is noted:

headaches;
signs of intoxication;
depressive state;
dizziness;
high blood pressure, tachycardia;
tremor of the upper limbs;
feeling of dryness in the mouth.

Take an antihistamine with plenty of water

"Cetrin" during early pregnancy

After fertilization of the egg, the period of embryo formation begins, which covers the first 13 weeks. At this time, the laying of organs and systems takes place. Reproducing fetal cells are sensitive to external influences.

The use of pharmacological products at an early gestational age is fraught with serious pathological disorders.

A weak placental barrier does not create hope of protection against the penetration of medicinal components, as a result - the development of fetal hypoxia, spontaneous abortion.

The ability of an antihistamine drug to affect the fetus is determined by the physiological characteristics of the patient and the state of the placenta, course and dosage.

Contraindications "Cetrin" during pregnancy in the 1st trimester indicate an increase in the likelihood of side effects, but this does not mean that pathological changes are characteristic of each clinical case.

Therefore, in order to prevent the risk of a defective unborn child, it is advisable to take increased care of your health and your baby in order to eliminate the need for medical treatment.

Method of application and dosage

The tablet form of release of an antiallergic product has become widespread in ENT practice. 1 tablet contains 10 mg. cetirizine dihydrochloride. This is a one-time rate for adults. With reduced kidney function, the dose is halved - half a tablet (5 mg). The daily multiplicity is limited to two receptions.

For reference! In chronic renal failure, "Cetrin" is prescribed 5 mg. in one day.

The duration of the drug regimen determines the form of the lesion, the etiology of the pathogen, the general course of the clinical picture. In order to prevent the course of application varies from 2 weeks to a month.

For therapeutic purposes, it is prescribed for a cycle of 14 days to six months. The drug effect persists for the next 3 days after discontinuation of the drug.

Self-medication with the manifestation of allergic symptoms is strictly contraindicated throughout the entire gestational period

The process of digestion does not slow down the period of absorption of the active ingredients, so it is allowed to take the tablets before or after meals with plenty of water.

The scheme for taking the liquid form does not differ from the previous variation. From the age of twelve appoint 10 ml. syrup twice a day, provided there are no pathological disorders of the kidneys.

Conclusion

Before using "Cetrin" it is recommended to study the annotation to prevent the development of side effects. The 3rd generation antihistamine drug shows a high therapeutic effect in a sparing form for allergic rhinitis, conjunctivitis, hay fever, dermatosis, in complex therapy for bronchial asthma.

Minimal risks of developing side effects from the use of the drug are observed in the 2nd trimester of pregnancy. Therefore, early and late terms are contraindications for the appointment.

gorlonos.com

Cetrin: indications for use, analogues

Hello friends! Today I want to tell you about the drug cetrin, the indications for the use of which promise to cope with allergies.

It's no secret that there are a lot of drugs that stop allergic attacks, but I want to talk about this remedy: its advantages and disadvantages.

In the next article, by the way, you can read what Cetrin tablets are prescribed for.

Cetrin indications for use

Beforehand, I consider it necessary to write 2 medical facts:

Any irritants, getting inside, meet a powerful rebuff from immune cells.
There are situations when the immune system weakens and then the control over the production of histamines disappears: they begin to form in large quantities and adversely affect all human tissues and organs.

Antihistamines come to the rescue in such situations. Today, three generations of antihistamines are used in clinical practice. The first generation includes:

tavegil,
fenistil,
diazolin

Reading the indications for the use of each of them, one can come to the conclusion that they all have a powerful suppressive effect.

But, unfortunately, this affects the manifestation of an equally strong side effect - drowsiness.

Third generation drugs (claritin, telfast, erius) have the same strong qualities in suppressing the production of histamine, and are practically devoid of side effects.

And what are the specific indications for use of tsetrin?

It belongs to the second generation of antihistamines and has a wider spectrum of action. It does not have a very pronounced side effect, but it also affects the receptors more gently.

The active ingredient, cetirizine, binds to receptors and prevents histamine from reaching them. This means that allergic manifestations such as:

And this happens already at the cellular level. In addition, it does not allow eosinophils to accumulate in the focus of inflammation, and, accordingly, prevents the development of the inflammatory process at the site of an allergic reaction.

Due to such qualities and indications, it can be prescribed for the treatment of allergies not only for adults, but also for children over 2 years old.

Let's now try to figure out: what is said in the indications for use about pregnancy ...

Cetrin during pregnancy

Before talking about the possibility of its use during pregnancy, I want to tell you: why, in general, antihistamines are forbidden to be taken by expectant mothers.

During pregnancy, histamine becomes a very necessary component. With its assistance, the fertilized egg is attached to the wall of the uterus.

It promotes the development of the embryo, and further regulates the metabolism of the fetus. The formation of tissues and organs of the baby depends on it.

Important to remember!

Taking medications that suppress the production of histamine can have a tragic effect on the condition of the child, his physical and mental development.

Here are the indications for use during pregnancy:

if you start using it, it can negatively affect the functioning of the kidneys and liver. Therefore, tsetrin during pregnancy has, of course, advantages over other drugs, but is used with great care.

ALWAYS, you need to consult with a specialist in the place, and then, if you are allowed to use it, do it under the strict supervision of a doctor.

The drug has few side effects, and does not affect the quantitative production of histamines.

But, nevertheless, during the first 12 weeks, its use is generally prohibited. And in the future, doctors look at the health of the mother and fetus.

It is also worth mentioning that the drug is produced by an Indian pharmaceutical company, but are there any analogues in domestic production?

Cetrin analogs

Comparing the indications for use of cetrin and looking through the reference books, I found a number of domestically produced medicines that are similar in their action.

All dosage forms produced on the basis of cetirizine and being histamine blockers can be considered analogues.

Therefore, here are the analogues of tsetrin for you:

Fesco tablets,
- ceresa,
- Ketotifen,
- clarifer,
- Xizal,
- Telfast.
- Syrups Clargotil,
  - Claridol,
  - Loratadine,
  - Peritol.

If we compare in general the indications for the use of some other drugs, which are sometimes called "synonyms", this is another separate list.

This includes all drugs based on cetirizine, and slightly different additional components.

Alerza,
cetirizine,
Letizen,
Zyrtec.

The list can go on for a very long time. Now, knowing what indications Cetrin has for use, you must decide: do you want to start using it?

primenimudrost.ru

Antihistamines during pregnancy

The appearance of an allergy does not bring joy to anyone. And during pregnancy, it is also fraught with danger. This often happens to women who are naturally prone to allergic reactions. But if earlier they used those drugs that are most suitable for them, then with the onset of pregnancy, everything changes dramatically. So, let's find out how to save expectant mothers? What antihistamines are they allowed to take?

Features of allergies during pregnancy

Such a reaction can also occur in those women who have not previously suffered from allergies. And this is due to a change in the functioning of the immune system. If the expectant mother is allergic by nature, then allergic manifestations can be expressed in varying degrees - from mild to very severe. Their main types in pregnant women are:

Rhinitis. This is the most common sign that can occur from the second trimester.
Conjunctivitis. It is in most cases combined with rhinitis.
Contact dermatitis or eczema. The latter is a thickening and swelling of the epidermis, its redness, itching.
Hives. In severe cases, it can develop into Quincke's edema.
Signs of bronchial asthma. The risk of its exacerbation increases at the end of the second trimester.

Allergy of the expectant mother is the risk of fetal hypoxia after placental vasospasm. The reasons for its manifestations are seasonal phenomena, the use of allergen products, contact with household chemicals, and other negative effects.

About the types of antihistamines

Today there are three generations. These drugs have the same principle of action. But the differences lie in the attachment of drug molecules to receptors in the body.

The body of a pregnant woman reacts in a peculiar way to previously familiar products and phenomena.

Therefore, it is not surprising that expectant mothers are prone to allergic reactions much more often than others: they have allergies in both mild and severe forms and depend on the use of certain drugs, the use of certain foods, or on a certain period of time when plants bloom or fruits ripen.

What is histamine and its role in the body of a pregnant woman

In addition to the fact that histamine is a well-known mediator of allergic reactions, it is also an equally well-known regulator of physiological processes.

In a pregnant body, histamine becomes a very important hormone, in the earliest stages, thanks to this component, a fertilized egg attaches to the wall of the uterus, and in later periods, histamine contributes to the normal development of the fetus and becomes the main regulator of metabolism.

It depends on the amount of histamine in the mother's body in the future how adequately the tissues and organs of the baby will be formed.

Cetrin from a number of antihistamines

Which of the drugs to choose a pregnant woman with allergies? The first thing that comes to mind is Tsetrin.

The medicine is effective, not very expensive, and advertising is placed in almost all mass media.

But such an availability of the drug should, at a minimum, make the future mother think and consult a doctor.

Cetrin is excluded from their number, but if other anti-allergic drugs do not help, doctors make an exception by prescribing Cetrin to pregnant women, provided that they are taken with great care and constant monitoring on their part.

Cetrin represents the second generation of antihistamines and differs from first generation drugs in a milder effect on receptors and less side effects.

Composition, effects and pharmacokinetics of the drug

The active ingredient in Cetrin is cetirizine.

Excipients:

lactose;
magnesium stearate;
povidone;
corn starch.

The active substance at the cellular level binds to receptors and blocks the flow of histamine and prevents the manifestation of rash, itching, hyperemia.

Another feature of the effect of the drug is to effectively counteract the accumulation of eosinophils in the focus of inflammation and prevent the development of the inflammatory process.

Cetrizine is absorbed from the gastrointestinal tract, and food intake has little effect on absorption, so there is not much difference when taking the pill: before, after or during meals.

Metabolic processes are concentrated in the liver, the half-life is from 5 to 12 hours, depending on the age of the patient (the older he is, the longer the excretion).

The drug is excreted in the urine.

Indications for use

Allergic reactions that are seasonal or chronic in nature:

allergic rhinitis;
allergic conjunctivitis;
itching of various adventures;
hives;
angioedema.

Pregnancy as a contraindication

In the instructions for the drug, pregnancy and the lactation period are indicated by contraindications to the use of Cetrin.

And any physician will confirm that taking drugs that suppress the effect of histamine in pregnant women can cause such negative consequences as a violation of the mental and physical development of the fetus.

As for the mother's well-being, pregnant women taking Cetrin often complain about the negative effect of the drug on the functioning of the kidneys and liver.

Therefore, even if the allergy is too painful, do not take the drug on your own - an easy solution can later be very expensive.

Tsetrin by trimesters

1 trimester

2nd trimester

3rd trimester

Source: http://spuzom.com/cetrin-pri-pregnancy.html

Cetrin: instructions for use - Yandex.Health

Film-coated tablets white or almost white, round, biconvex, with a risk on one side.

Excipients: lactose - 106.5 mg, corn starch - 65 mg, povidone K30 - 2 mg, magnesium stearate - 1.5 mg.

The composition of the film shell: hypromellose - 3.3 mg, macrogol 6000 - 0.661 mg, titanium dioxide - 0.706 mg, talc - 1.183 mg, sorbic acid - 0.05 mg, polysorbate 80 - 0.05 mg, dimethicone - 0.05 mg.

10 pieces. - blisters (2) - packs of cardboard.
10 pieces. - blisters (3) - packs of cardboard.

Histamine H1 receptor blocker. Cetirizine is a hydroxyzine metabolite and a competitive histamine antagonist. Prevents the development and facilitates the course of allergic reactions, has antipruritic and antiexudative action.

It affects the early histamine-dependent stage of allergic reactions, limits the release of inflammatory mediators at the late stage of an allergic reaction, reduces the migration of eosinophils, neutrophils and basophils, and stabilizes mast cell membranes.

Reduces the permeability of capillaries, prevents the development of tissue edema, relieves spasm of smooth muscles. Eliminates skin reaction to the introduction of histamine, specific allergens, as well as to cooling (with cold urticaria).

Reduces histamine-induced bronchoconstriction in mild bronchial asthma.

Cetirizine does not have anticholinergic and antiserotonin effects. In therapeutic doses, it does not have a sedative effect.

The effect after taking drops in a single dose of 10 mg develops after 20 minutes in 50% of patients and after 60 minutes in 95% of patients, lasts more than 24 hours.

After taking the tablet, the effect occurs after 20 minutes. Against the background of course treatment, tolerance to the antihistamine action of cetirizine does not develop.

After stopping treatment, the effect persists for up to 3 days.

The pharmacokinetic parameters of cetirizine change linearly when the drug is prescribed at a dose of 5-60 mg.

Suction

After oral administration, cetirizine is rapidly and completely absorbed from the gastrointestinal tract.

Eating does not affect the completeness of absorption, although the rate of absorption decreases and the value of Cmax decreases by 23%.

In adults, after a single dose of the drug in a therapeutic dose, Cmax in blood plasma is reached after 1 ± 0.5 hours and is 300 ng / ml.

Distribution

Plasma protein binding is 93 ± 0.3% and does not change at cetirizine concentrations in the range of 25-1000 ng / ml. Vd is 0.5 l/kg. When taking the drug at a dose of 10 mg for 10 days, no accumulation of cetirizine is observed. Cetirizine is excreted in breast milk.

Metabolism

It is metabolized in small amounts in the body by O-dealkylation (unlike other histamine H1 receptor antagonists, which are metabolized in the liver with the participation of the cytochrome P450 system), with the formation of a pharmacologically inactive metabolite.

breeding

In adults, T1 / 2 is approximately 10 hours. About 2/3 of the accepted dose of the drug is excreted in the urine unchanged, 10% - with feces. Systemic clearance - 53 ml / min.

Pharmacokinetics in special groups of patients

In elderly patients and patients with chronic liver diseases, with a single dose of the drug at a dose of 10 mg, T1 / 2 increases by about 50%, and systemic clearance decreases by 40%.

T1 / 2 in children aged 6 to 12 years is 6 hours, aged 2 to 6 years - 5 hours, aged 6 months to 2 years - 3.1 hours.

In patients with mild renal insufficiency (CC> 40 ml / min), pharmacokinetic parameters are similar to those in patients with normal renal function.

In patients with moderate renal insufficiency and in patients on hemodialysis (CC 80 ml / min (normal) or 50-79 ml / min (mild renal insufficiency), the drug is prescribed in the usual dosage regimen - 10 mg (1 tab. or 20 drops) / day.

At CC from 30 to 49 ml / min (moderate degree of renal failure) the drug is prescribed 5 mg (1/2 tab. or 10 drops) of the drug 1 time / day. At CC from 10 to 29 ml / min (severe stage of renal failure) 5 mg (1/2 tab. or 10 drops) every other day.

At CC less than 10 ml / min (end-stage renal disease) the use of the drug is contraindicated.

CC (ml / min) \u003d × body weight (kg) / 72 × CC serum (mg / dl).

At combination of renal and hepatic insufficiency the drug is also prescribed in the above mode.

With normal renal function, correction of the dosing regimen is not required.

Elderly patients with normal renal function, dose adjustment is not required.

Possible side effects are listed below by body systems and frequency of occurrence: very often (> 1/10); often (1/10-1/100); infrequently (1/100-1/1000); rarely (1/1000-1/10,000); very rarely (10 ml / min correction of the dosing regimen is required); patients with predisposing factors for urinary retention; with epilepsy and patients with increased convulsive readiness; elderly patients (with an age-related decrease in glomerular filtration); in childhood up to 1 year (for drops).

Experimental studies on animals did not reveal any direct or indirect adverse effects of cetirizine on the developing fetus (incl.

in the postnatal period), the course of pregnancy and childbirth also did not change.

Adequate and strictly controlled clinical studies on the safety of the drug during pregnancy have not been conducted, so cetirizine should not be used during pregnancy.

Cetirizine is excreted in breast milk, so the issue of stopping breastfeeding for the period of drug use should be decided.

Patients with impaired liver function with normal renal function, correction of the dosing regimen is not required. cetirizine is excreted mainly by the kidneys, when the drug is prescribed patients with renal insufficiency the dose should be adjusted depending on the size of the CC.

The use of the drug in the form of drops in children under 6 months is contraindicated, due to the limited data on the efficacy and safety of the drug; in the form of tablets - in children under 6 years of age.

With caution, the drug in the form of drops should be prescribed to children under the age of 1 year.

FROM caution the drug should be prescribed to elderly patients (with an age-related decrease in glomerular filtration).

In patients with spinal cord injury, prostatic hyperplasia, as well as in the presence of other predisposing factors for urinary retention, caution is required, because. cetirizine may increase the risk of urinary retention.

Methyl parahydroxybenzoate and propyl parahydroxybenzoate, which are part of the drug in the form of drops, can cause allergic reactions, incl. slow type.

Before prescribing allergological tests, a three-day “washout” period is recommended due to the fact that inhibitors of histamine H1 receptors (including cetirizine) inhibit the development of skin allergic reactions.

When exceeding the dose of 10 mg / day, the rate of psychomotor reactions may slow down.

Pediatric use

In view of the potential depressant effect on the central nervous system, caution should be exercised when prescribing cetirizine drops to children under the age of 1 year with the following risk factors for sudden infant death syndrome (but not limited to this list):

- sleep apnea syndrome or sudden infant death syndrome in infants in a brother or sister;

- maternal drug or tobacco abuse during pregnancy;

- young age of the mother (19 years and younger);

- Tobacco abuse of a nanny caring for a child (1 pack of cigarettes per day or more);

- children who regularly fall asleep face down, who are not laid on their backs;

- premature (less than 37 weeks of gestation) or born with insufficient body weight (below the 10th percentile of gestational age);

- the combined use of drugs that have a depressing effect on the central nervous system.

Influence on the ability to drive vehicles and control mechanisms

An objective assessment of the ability to drive vehicles and control mechanisms did not reliably reveal any adverse events when taking the drug at the recommended dose, but during the period of treatment it is advisable to refrain from driving vehicles and other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions .

Symptoms: with a single dose of cetirizine at a dose of 50 mg, confusion, diarrhea, dizziness, fatigue, headache, malaise, mydriasis, itching, anxiety, weakness, sedation, drowsiness, stupor, tachycardia, tremor, urinary retention were noted.

Treatment: immediately after taking the drug - gastric lavage or stimulation of vomiting. It is recommended to take activated charcoal, conduct symptomatic and supportive therapy. There is no specific antidote. Hemodialysis is ineffective.

When studying the pharmacokinetic interaction of cetirizine with pseudoephedrine, cimetidine, ketoconazole, erythromycin, azithromycin, glipizide, diazepam and antipyrine, no clinically significant undesirable interaction was detected.

With simultaneous use with theophylline (400 mg / day), the total clearance of cetirizine is reduced by 16% (the kinetics of theophylline does not change).

With simultaneous use with ritonavir, the AUC of cetirizine increased by 40%, while that of ritonavir changed slightly (-11%).

Simultaneous use with antibiotics of the macrolide group (azithromycin, erythromycin) and ketoconazole does not lead to changes in the ECG of patients.

At therapeutic doses, cetirizine did not show a clinically significant interaction with ethanol (at a blood ethanol concentration of 0.5 g/l). However, you should refrain from drinking alcohol.

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C. The shelf life of tablets is 2 years, drops - 3 years.

The drug is released without a prescription.

Source: https://health.yandex.ru/pills/cetrin-951

Tsetrin

Cetrin is a drug for relieving allergy symptoms.

Release form and composition of Tsetrin

Cetrin is available in vials as a clear, colorless syrup with a fruity odor and as white, film-coated tablets.

The main active ingredient of Cetrin is cetirizine dihydrochloride.

Excipients of Cetrin tablets are corn starch, lactose, magnesium stearate, povidone. The composition of the film shell includes macrogol 6000, talc, hypromellose, titanium dioxide, polysorbate 80, sorbic acid, dimethicone.

The auxiliary substances of the syrup are sucrose, glycerol, benzoic acid, disodium edetate, sorbitol solution, sodium citrate, purified water, fruit flavor.

Pharmacological action of Cetrin

Cetrin is a histamine antagonist, H1-histamine receptor blocker, hydroxyzine metabolite. Facilitates the course of allergy symptoms and prevents their occurrence, has an anti-exudative and antipruritic effect.

Reduces the permeability of small blood vessels, prevents swelling, eliminates spasms of smooth muscles.

It affects the initial stage of allergy symptoms, reduces the release of inflammatory mediators, the migration of basophils, neutrophils, eosinophils.

In bronchial asthma, it reduces mild histamine-induced bronchoconstriction. Removes the reaction on the skin to the introduction of specific allergens, histamine, to the action of cold.

Almost no anticholinergic and antiserotonin effect.

When taking Cetrin in therapeutic doses, there is no sedative effect.

The drug begins to act 20 minutes after taking it. Valid for over 24 hours.

There is no addiction to cetirizine during course treatment.

The action of Tsetrin after the end of its use lasts about 72 hours.

Indications for use Cetrin

According to the instructions, Tsetrin is prescribed for:

Contraindications to the use of Cetrin

According to the instructions, Tsetrin is not used for:

hypersensitivity to the components included in its composition;
pregnancy and lactation;
as well as under the age of 2 years.

Caution Cetrin is prescribed for moderate and severe chronic renal failure and in old age.

Method of application and dosage of Cetrin

According to indications, Cetrin is taken orally with a few sips of water.

It is preferable to take the drug at night.

Dosage of the drug:

adults and children over 6 years old - once a day, 10 mg (or 10 ml of syrup), or twice a day, 5 mg (or 5 ml of syrup).
children 2-6 years old - once a day, 5 mg or 5 ml of syrup, or twice a day, 2.5 mg or 2.5 ml of syrup.
patients with impaired renal function - once a day 5 mg (5 ml);
patients with severe chronic renal failure - every other day, 5 mg (5 ml).

In elderly people with intact renal function, no dose adjustment is required.

Side effects of Cetrin

According to reviews of Cetrin, as a rule, patients tolerate well.

Sometimes the drug can cause side effects in the form of dry mouth, drowsiness, headache, migraine, dizziness, discomfort in the gastrointestinal tract (flatulence, abdominal pain, dyspepsia), allergic reactions (skin rash, itching, urticaria, angioedema edema).

Overdose

According to reviews to Tsetrin, an overdose of the drug is manifested by drowsiness. In the case of a severe overdose (exceeding the recommended dosage by 30-40 times), anxiety, drowsiness, rash, itching, fatigue, urinary retention, tachycardia, tremor occur.

For the treatment of overdose, gastric lavage and symptomatic therapy, if necessary, are used.

Use during pregnancy and lactation

During periods of pregnancy and breastfeeding, Cetrin is not prescribed.

Interaction with other drugs

Interactions with erythromycin, pseudoephedrine, ketoconazole, azithromycin, diazepam, cimetidine, glipizide have not been identified.

The appointment of Cetrin together with theophylline reduces the total clearance of cetirizine. The kinetics of theophylline remains unchanged.

It is necessary to carefully use Cetrin according to indications together with sedatives.

The hematotoxicity of the drug is enhanced by myelotoxic drugs.

special instructions

When using Cetrin according to indications, it must be borne in mind that:

in case of taking more than 10 mg of the drug per day, the speed of reactions may decrease;
the effect of ethanol is not enhanced by this drug, but it is not recommended to drink alcohol during treatment;
care should be taken when performing work related to the speed of reactions and high concentration of attention.

Tsetrin's analogs

Analogues of Cetrin include drugs such as Zincet, Allertec, Zodak, Zirtek, Cetirizine dihydrochloride, Cetirizine, Cetirizine DS, Cetirizine Geksal, Cetirizine TEVA, Cetirinax.

Storage conditions of Cetrin

Cetrin should be stored in a dark place, protected from children, at a temperature not exceeding 25ºС.

Source: http://zdorovi.net/preparaty/cetrin.html

Tsetrin: instructions for use

The drug Cetrin is an antiallergic agent from the group of histamine H1 receptor blockers.

Release form and composition of the drug

The drug Cetrin is available in the form of tablets for oral administration.

Tablets are white, enteric coated, convex on both sides, round, packed in blisters of 10 pieces (1-3) in a cardboard box, a detailed annotation describing the drug is attached to the drug.

Each tablet contains 10 mg of the active ingredient - Cetirizine dihydrochloride, as well as a number of additional excipients, including lactose monohydrate.

Indications for use

The drug Cetrin is prescribed to patients for the rapid removal of allergy attacks and the prevention of allergic reactions caused by such conditions:

allergic rhinitis, which often occurs during the flowering of grasses and ragweed;
allergic conjunctivitis;
urticaria, including idiopathic form;
hay fever;
lacrimation and severe rhinorrhea;
itching of the skin with dermatitis, eczema, neurodermatitis;
angioedema;
allergic reaction to UV radiation;
an allergic reaction to the stings of bees, mosquitoes, midges, horseflies.

Cetrin tablets are often prescribed to patients prone to allergies as a prophylactic when taking certain medications or eating allergenic foods.

Contraindications

Cetrin tablets have some restrictions on the use, therefore, before starting therapy, it is recommended that you carefully read the attached instructions. The drug is contraindicated in patients with the following conditions:

diseases of the kidneys or liver in a severe stage, accompanied by a violation of the function of the organ;
age up to 6 years (for this dosage form);
hypersensitivity to the components of the drug;
pregnancy and breastfeeding period;
lactose intolerance, malabsorption syndrome;
acute liver failure.

Also, the drug has a number of relative contraindications, when treatment is possible under the supervision of a doctor and at the lowest effective dosage. These restrictions are:

cardiac arrhythmias, in particular bradycardia;
epilepsy and other diseases of the central nervous system;
the patient's age is over 65 years.

Method of application and dosage

Since the drug Cetrin has a prolonged (long-term) effect, the tablets are taken only once a day at a dosage of 10 mg, preferably at night. The tablet is swallowed immediately, without crushing, washed down with a sufficient amount of water.

For children older than 6 years, the dose is calculated individually, depending on body weight indicators. Therapy begins with 5 mg (1/2 tablet) 1 time per day. The duration of therapy is determined by the doctor for each individual patient.

Use during pregnancy and lactation

Studies and clinical trials of the drug Cetrin and its effect on pregnancy and fetal development have not been conducted. Given the lack of information on the safety of tablets for the mother and fetus, Cetrin is not prescribed to pregnant women.

The active active ingredient of the tablets is excreted in breast milk and can penetrate the child's body, so the drug Cetirizine is not recommended for nursing mothers. If it is necessary to treat a nursing mother, it is recommended to resolve the issue of the completion of lactation.

Side effects

In most cases, the drug Cetrin is normally tolerated by patients, but if the dose is exceeded, hypersensitivity to the tablet components or intolerance to the tablet components, side effects may develop:

on the part of the digestive canal - dry mouth, intense thirst, heaviness in the stomach, burning along the esophagus, lack of appetite, sometimes nausea, constipation, abnormal liver function, increased activity of hepatic transaminases;
from the nervous system - dizziness, drowsiness, lethargy, increased fatigue, headache, irritability, apathy;
allergic reactions - skin rash, skin itching, urticaria, red spots on the cheeks, cough and sore throat of an allergic nature;
on the part of the cardiovascular system - changes in blood pressure, palpitations, chest pain, bradycardia, heart rhythm disturbance.

If one or more side effects occur, treatment with the drug should be stopped immediately and consult a doctor.

Overdose

In case of regular excess of the prescribed dose or prolonged uncontrolled use of tablets in large quantities, the patient develops signs of an overdose, which are clinically manifested by an increase in the described side effects, depression of consciousness, increased blood pressure and intraocular pressure, development of renal and hepatic insufficiency.

Treatment of an overdose consists in the immediate abolition of drug therapy, gastric lavage, the introduction of enterosorbents and symptomatic therapy, if necessary. Until the condition stabilizes, the patient should be under the supervision of a physician.

Interaction of the drug with other drugs

With the simultaneous appointment of Cetrin tablets with Theophylline, the clearance of Cetirizine decreases, which should be taken into account and this drug interaction should be avoided.

Under the influence of the drug Cetrin, the therapeutic effect of sedatives, antidepressants and psycholeptics is enhanced, so the patient may experience drowsiness, lethargy, lethargy during this drug interaction.

special instructions

Cetrin tablets should be used with caution in elderly patients, as they have reduced glomerular filtration in the kidneys, which increases the risk of side effects from the kidneys.

During treatment with Cetrin tablets, you should not drink alcohol, as this increases the risk of side effects from the central nervous system and increases the likelihood of toxic liver damage.

The drug in this dosage form is not prescribed to children under 6 years of age, since there is no experience in using tablets in this age group, and the safety of the drug has not been established. If it is necessary to prescribe an antihistamine for children under 6 years of age, the doctor selects a drug in the form of oral drops.

During drug therapy, you should refrain from driving a car and operating machinery that requires increased concentration. This is due to the likelihood of sudden dizziness and drowsiness under the influence of tablets.

Analogues of tablets Tsetrin

Analogues of the drug Cetrin are:

Zyrtec drops and tablets;
Cetirizine tablets and drops for oral administration;
Zodak drops;
Zodak Express tablets;
Claritin tablets, syrup;
Loratadine.

Before replacing the prescribed drug with its analogue, you should read the attached instructions for contraindications and age restrictions.

Vacation and storage conditions

Cetrin tablets are sold from pharmacies without a prescription. It is recommended to store the drug out of the reach of children, at a temperature not exceeding 25 degrees. The shelf life of tablets from the date of manufacture is 2 years, do not take orally after the expiration date.

Cetrine price

The cost of the drug Tsetrin in pharmacies in Moscow averages 175 rubles.

Cetrin is a third-generation antihistamine drug, manufactured by the Indian pharmaceutical company Dr. Reddy's Laboratories Ltd. Its main action is aimed at preventing the manifestation of allergic reactions, alleviating their symptoms.

If allergy treatment is started on time, when the first signs appear, then the drug is able to completely block unpleasant reactions; with a neglected form - reduce inflammation, reduce swelling, spasms. The therapeutic effect of Cetrin is manifested in the provision of antipruritic, antiexudative and antiallergic effects.

Also, the drug causes inhibition of the synthesis of stimuli, a decrease in leukocyte germ cells, increases the capacity of capillaries, thereby stopping the manifestation of symptoms of allergic reactions.

Release form

Cetrin on the pharmacological market is presented in the form of soluble coated tablets, drops for internal use and syrup.

Compound

The main active ingredient of Cetrin is cetirizine. This substance prevents itching, rashes and other allergic reactions by binding to receptors at the cellular level and blocking the flow of histamine.

The action of cetirizine appears 20-60 minutes after taking the drug, the duration of its effect persists for a day or three after stopping use.

Cetirizine is devoid of cardiotoxic sedative effect, so taking the drug does not cause drowsiness.

As auxiliary components are used:

in tablet form- lactose (milk sugar), cornstarch, magnesium stearate.
In drops- glycerol, propylene glycol, sodium hydrogen phosphate.
in syrup- sucrose, benzoic acid, 70% sorbitol solution, flavor.

Indications for use

Cetrin is prescribed for chronic or seasonal allergic reactions:

allergic rhinitis.
Allergic conjunctivitis.
Drug and food allergies.
Dermatoses of allergic origin.
Hives.
Quincke's edema.

Can pregnant women drink?

Cetrin has not been clinically tested on pregnant women, so there are no official data on its effect on the formation and development of the embryo.

In the instructions for the drug, pregnancy and lactation are indicated in the list of contraindications to taking the drug. This is explained simply: cetirizine, the main active ingredient, is able to penetrate the placenta and even enter breast milk.

The consequences of taking the drug are not fully understood, but can be very negative, up to the impact on the mental and physical development of the unborn child.

Reception of Cetrin is possible only in the most extreme cases, when allergies cannot be dealt with with the help of other drugs and methods, and only after consultation with a doctor, under his constant supervision.

In the early stages

The hormone histamine plays one of the important roles in the body of a pregnant woman in the first trimester: it is involved in the process of fixing the egg to the uterine wall. It is impossible to reduce the concentration of histamine in the blood, therefore taking Tsetrin before 12 weeks is strictly prohibited.

Violation of the prohibition may affect the normal course of pregnancy, because during the first three months the fertilized egg is fixed, all organs of the embryo are laid.

In the 2nd trimester

The toxic effect of Cetrin on the fetus is minimized in the 2nd trimester. An already more or less strengthened embryo continues to actively develop, receiving all the necessary nutrients from the mother's body. Histamine is also involved in this process, its suppression can provoke a slow development of the baby.

Taking an antihistamine is possible only as prescribed by a doctor, taking into account all indications and contraindications, subject to constant monitoring of the condition of the woman and the unborn child.

In the 3rd trimester

The unborn child is practically formed by the third trimester, during the last months he is gaining weight intensively. But histamine continues to play an important role in a woman's body, regulating the metabolic process and influencing the development of organs and tissues of the fetus. Therefore, Cetrin can be taken in cases of emergency and under medical supervision.

How to use?

Most often For pregnant women, the drug is prescribed in tablet form: 2 times a day for half a tablet (5 mg of cetirizine), while the daily dose for an adult is 1 time per day for a whole tablet (10 mg of cetirizine).

For women in position with problems with the kidneys or liver, the recommended dose is ½ tablet 1 time in 2 days. But perhaps the doctor will prescribe a different treatment regimen.

The drug can be taken before, during, after meals, since the active substance is absorbed in the gastrointestinal tract, and the diet has practically no effect on this process.

Contraindications

The drug is excreted from the body with urine, so those who have a history of kidney problems should refrain from taking it.
Also, women with various liver diseases should not use the medicine.
If you do not consider the pregnancy itself as a contraindication to taking Cetrin, then the first trimester must necessarily proceed without this medication. A still weak placenta is not able to protect the fetus from the toxic effects of the drug, and this is fraught with serious pathological disorders: fetal hypoxia, spontaneous abortion.

Adverse reactions

In case of an overdose of Cetrin or sensitivity to its individual components, the following side effects are possible:

Headache.
Tremor of the upper limbs.
Increase in blood pressure.
Tachycardia.
Vertigo.
Dry mouth.
Signs of intoxication.
Increased fatigue.
State of depression, confusion.

If at least one of the listed symptoms appears, the drug should be stopped immediately and immediately visit the doctor who prescribed this medicine.

Analogues

All of the drugs listed below have a common characteristic: they block histamine in the body of a woman. Therefore, they should be used only after the appointment of a doctor and under his supervision. Also, all medicines are not recommended to be taken in the first trimester.

Suprastin- a fast-acting drug that can cope with the manifestations of allergic reactions. It is considered one of the most gentle medicines for a pregnant woman.
Diazolin- one of the most famous antihistamines that copes with allergies, even in a chronic form. One of the disadvantages is the short duration of exposure: the medicine must be taken three times a day.
Loratadine (Claritin)- preparations in which the main active ingredient - loratadine - provides a quick effect on the woman's body, resulting in relief comes after 15 - 20 minutes after administration.
Zodak (Zyrtec)- the main component of the drugs is the same as in Tsetrin - cyteresin, so the appointment is possible if the issue of normalizing the mother's well-being is more important than the possible risks of fetal development.
Fenistil- one of the safest drugs, which is prescribed even for infants. Available in the form of a drop and a gel.

Folk remedies and methods of prevention

In the treatment of any disease during pregnancy, it is more expedient for a future mother to resort to the help of traditional medicine. Alternative methods of treatment are not inferior to pharmacological drugs in terms of their effect, but in terms of the naturalness of the components used, they are significantly superior to them.

Pregnant women can use one of the following recipes, but it would be more correct if this also happens after consulting a doctor:

Nasal congestion and allergic rhinitis can be alleviated or cured with inhalations based on essential oils (tea tree eucalyptus, pine, fir, creeping thyme, lemongrass). You can also pour mineral water without gases into the nebulizer and breathe its vapors for some time.
Drops made from aloe juice or Kalanchoe drops can reduce the amount of discharge from the nose. The same drops will help to cope with nasal congestion without having a vasoconstrictor effect, which can provoke fetal hypoxia.
Decoctions will help to cope with bronchospasm, prepared on the basis of plantain, chamomile, wormwood, sage, St. John's wort, nettle, yarrow. To prepare them, you need to take 2 tbsp. crushed dry raw materials, pour a glass of boiling water and boil in a water bath for 15 - 20 minutes. The resulting decoctions can be used to rinse the mouth, but it can be taken orally only in the early stages.
Skin itching can reduce compresses based on decoction of oak bark(100 g of the substance is boiled in 1 liter of water for half an hour). Rosehip oil will also help: it is taken orally (1 tsp 3 times a day) or it is rubbed on problem areas of the skin.
Fresh cabbage leaf is the best option for solving the problem of skin dermatitis at all times. He is tied for several hours to a problematic place, periodically changing to a fresh one.

An allergy attack can “play out” at the most inopportune moment. Unfortunately, waiting time for a baby is no exception. At this time, the expectant mother needs to think first of all about the baby, its normal development, so taking any medication is possible only after consulting a doctor.

Cetrin is a possible solution to the problem, but only in the second trimester. Do not self-medicate: it can cost you a lot!

What is histamine and its role in the body of a pregnant woman

It depends on the amount of histamine in the mother's body in the future how adequately the tissues and organs of the baby will be formed.

Cetrin from a number of antihistamines

Which of the drugs to choose a pregnant woman with allergies? The first thing that comes to mind is Tsetrin. The medicine is effective, not very expensive, and advertising is placed in almost all mass media.
But such an availability of the drug should, at a minimum, make the future mother think and consult a doctor.

Cetrin represents the second generation of antihistamines and differs from first generation drugs in a milder effect on receptors and less side effects.

Composition, effects and pharmacokinetics of the drug

The active ingredient in Cetrin is cetirizine.

Excipients:

lactose;
magnesium stearate;
povidone;
corn starch.

The active substance at the cellular level binds to receptors and blocks the flow of histamine and prevents the manifestation of rash, itching, hyperemia.

Another feature of the effect of the drug is to effectively counteract the accumulation of eosinophils in the focus of inflammation and prevent the development of the inflammatory process.

Cetrizine is absorbed from the gastrointestinal tract, and food intake has little effect on absorption, so there is not much difference when taking the pill: before, after or during meals.

Metabolic processes are concentrated in the liver, the half-life is from 5 to 12 hours, depending on the age of the patient (the older he is, the longer the excretion).

The drug is excreted in the urine.

Indications for use

Allergic reactions that are seasonal or chronic in nature:

allergic rhinitis;
allergic conjunctivitis;
itching of various adventures;
hives;
angioedema.

Pregnancy as a contraindication

As for the mother's well-being, pregnant women taking Cetrin often complain about the negative effect of the drug on the functioning of the kidneys and liver.

Therefore, even if the allergy is too painful, do not take the drug on your own - an easy solution can later be very expensive.